Baker’s Yeast Beta-Glucan Supplement Reduces
Allergy Symptoms and Improves Quality of Life in Ragweed Sufferers
Presented to Experimental Biology 2011, Washington, D.C.
Shawn M. Talbott, Julie A. Talbott, Tracy L. Talbott, and Elaine Dingler.
SupplementWatch, Draper, UT
Ragweed is a leading cause of seasonal allergy symptoms and
affects 36 million Americans. Typical symptoms include nasal
congestion, sneezing, itchy eyes, and difficulty breathing caused by
an immune system overreaction to ragweed pollen. Several studies
show Baker’s yeast beta-1,3/1,6 D-glucan (BG), extracted from
Saccharomyces cerevisiae is effective in reducing the incidence of
cold/flu symptoms. This study evaluated the effect of a BG
supplement (Wellmune) on allergy symptoms, ragweed-specific
IgE, and quality of life (QOL) indices in self-described ragweed
sufferers. Forty-eight healthy subjects consumed a placebo (P,
N=24) or 250mg of Wellmune (W, N=24) daily for 4-weeks
during Sept/Oct (high local pollen count). Allergy surveys,
including the validated Rhinoconjunctivitis Quality of Life
Questionnaire (RQLQ), were used to assess differences in allergy
symptoms. There were no differences between groups on IgE
markers. Subjects in the Wellmune group reported fewer allergy
symptoms (W = 4.2 v. P = 5.8) and reduced severity of allergy
symptoms (W = 6.9 v. P = 14.3) compared to placebo (p<0.05).
Subjects in the Wellmune group reported significant reductions in
nasal (W = 0.7 v. P = 1.6) and eye symptoms (W = 0.6 v. P = 0.8)
with a 56% improved QOL Index. These data show that daily
supplementation with Wellmune reduces allergy symptoms and
improves quality of life in individuals that suffer from ragweed
This study was conducted by SupplementWatch and sponsored by Biothera.