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Research Abstract


Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women

Journal of the American College of Nutrition, August 2012, vol 31,
no. 4, 295-300

Shawn M. Talbott, PhD,FACN, and Julie A. Talbott, MBA
SupplementWatch, Draper, Utah
Key words: dietary supplements, stress, beta-glucan, immune support

Objective: Several studies have shown a baker’s yeast beta-1,3/1,6-D-glucan, extracted from Saccharomyces cerevisiae, is effective in reducing the incidence of cold and flu symptoms. This study evaluated the effect of a specific beta-glucan supplement (Wellmune) on upper respiratory tract symptoms and psychological well-being in women with moderate levels of psychological stress.


Methods: Healthy women (38 6 12 years old) prescreened for moderate levels of psychological stress, selfadministered a placebo (n¼38) or 250 mg of Wellmune (n¼39) daily for 12 weeks. We used the Profile of Mood States (POMS) psychological survey to assess changes in mental/physical energy levels (vigor) and overall wellbeing (global mood state). A quantitative health perception log was used to track upper respiratory symptoms.


Results: Subjects in the Wellmune group reported fewer upper respiratory symptoms compared to placebo (10% vs 29%), better overall well-being (global mood state: 99 6 19 vs 108 6 23, p , 0.05), and superior mental/physical energy levels (vigor: 19.9 6 4.7 vs 15.8 6 6.3, p , 0.05).


Conclusions: These data show that daily dietary supplementation with Wellmune reduces upper respiratory symptoms and improves mood state in stressed subjects, and thus it may be a useful approach for maintaining
immune protection against daily stressors.



Immune Health Basics products contain Wellmune WGP®

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