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Scientific Literature

You are now entering the scientifc library portion of our web site. The information contained in this section is intended to provide you with a balanced overview of information relating to the safety and efficacy of Wellmune, the active ingredient in Immune Health Basics. 


Wellmune is a beta 1,3/1,6 glucan derived from a proprietary strain of baker's yeast.  Its molecular structure is unique and results in biological activity that cannot be replicated by other immune health products.  These articles are intended for general education purposes. This section does not constitute labeling, endorsements or advertisements and should not be interpreted as recommending how to treat any particular diseases or health-related conditions.


Biothera 's research program has generated the following studies, which include both clinical and preclinical research. Follow the links below for the official abstracts for each study.


February 2013
Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women
Journal of the American College of Nutrition, August 2012, vol 31,
no. 4, 295-300


December 2012
β-Glucan supplementation, allergy symptoms, and quality of life in self-described ragweed allergy sufferers
Food Science & Nutrition .doi: 10.1002/fsn3.11

August 2012
Modification of a Beta Glucan Affects Aggregation Behavior and Biological Activity
Presented to the International Carbohydrate Symposium
Madrid, Spain


July 2012
Baker's Yeast Beta-Glucan Supplementation Improves Post-Exercise Mucosal Immunity and Reduces Cold/Flu Symptomatic Days in Marathon Runners
Presented to the National Strength and Conditioning Association Providence, RI.

May 2012
Baker’s Yeast Beta Glucan Supplementation Reduces the Number of Cold/Flu Symptomatic Days After Completing a Marathon
Presented to the American College of Sports Medicine, San Francisco, CA.

May 2012
Baker's Yeast β-glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications for Infection Risk?
British Journal of Nutrition, FirstView Article: pp 1-9 copyright © the authors 2012.

April 2012
Influence of Yeast-Derived 1,3/1,6 Glucopolysaccharide on Circulating
Cytokines and Chemokines with Respect to Upper Respiratory Tract Infections

Nutrition 28: 665–669.

July 2011
The Effects of Yeast β-Glucan Supplementation on Monocyte and Cytokine Response to Exercise.
Presented to the International Society of Exercise Immunology, University of Oxford, UK.

April 2011
Activation of the Innate Immune Receptor Dectin-1 upon Formation of a ‘Phagocytic Synapse’
Nature 472, 471–475.

April 2011
Baker’s Yeast Beta-Glucan Supplement Reduces Allergy Symptoms and Improves Quality of Life in Ragweed Sufferers
Presented to Experimental Biology 2011, Washington, D.C.


December 2010
A randomised controlled trial to assess the ability of yeast-derived 1,3/1,6 glucopolysaccharide to reduce upper respiratory tract infection symptoms.
Presentation:  The British Society of Immunology. Publication pending


April 2010

Beta-glucan Supplement Reduces Upper Respiratory Tract Infections and Improves Mood State in Healthy Stressed Subjects

Presentation: Experimental Biology, 2010.  Publication pending.


February 2010
Beta 1,3/1,6 Glucan Decreases Upper Respiratory Tract Infection Symptoms and Improves Psychological Well-being in Moderate to Highly-Stressed Subjects.
Agro Food Industry Hi-Tech (2010) 21:21-24.


December 2009
Effect of Beta 1, 3/1, 6 Glucan on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes.
Journal of Sports Science and Medicine (2009). 8:509-515.


July 2009
Randomized Phase II Clinical Trials of Wellmune WGP® for Immune Support During Cold and Flu Season.
The Journal of Applied Research (2009) 9:20-42.


May 2008

Effects of an Immunomodulating Supplement on Upper Respiratory Tract Infection Symptoms in Wildland Firefighters.

Presentation: American College of Sports Medicine. Publication pending.



Immune Health Basics products contain Wellmune WGP®

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